Somatostatin modulates the behavioral effects of dopamine receptor activation in parkinsonian rats
Identifieur interne : 003053 ( Main/Exploration ); précédent : 003052; suivant : 003054Somatostatin modulates the behavioral effects of dopamine receptor activation in parkinsonian rats
Auteurs : J. Q. Lu [Canada] ; A. J. Stoessl [Canada]Source :
- Neuroscience [ 0306-4522 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Somatostatin may play a role in several neuropsychiatric disorders, including Parkinson's disease. Although functional interactions between somatostatinergic and dopaminergic transmitter systems have been well documented, no study has been conducted in animals with experimental Parkinsonism to explore the effects of somatostatin on dopamine receptor-mediated behavior. In the present study, rats with unilateral 6-hydroxydopamine-induced destruction of the medial forebrain bundle were assessed following administration of the dopamine1/2 receptor agonist apomorphine. Ipsilateral intrastriatal infusion of somatostatin produced a dose-related inhibition of apomorphine-induced rotations with maximal effect at a dose of 7.5 μg in 2 μl. This inhibitory effect of somatostatin was antagonized by the somatostatin antagonist cyclo-somatostatin (0.1 μg in 2 μl, intrastriatally). Neither somatostatin (up to 15 μg in 2 μl) nor cyclo-somatostatin on its own induced rotations; similarly, this dose of cyclo-somatostatin did not affect apomorphine-induced rotations. From these results we suggest that exogenous somatostatin, by directly acting on its specific receptors in the striatum, inhibits the effects of dopamine receptor activation in parkinsonian rats. We conclude that therapies based on modulation of somatostatin may be worth exploring in the management of Parkinson's disease and other disorders of the basal ganglia.
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Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Purdy Pavilion, 2221 Wesbrook Mall</s1><s2>Vancouver, BC, V6T 2B5</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC, V6T 2B5</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0446081</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0446081 INIST</idno><idno type="RBID">Pascal:02-0446081</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B64</idno><idno type="wicri:Area/PascalFrancis/Curation">000159</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000988</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000988</idno><idno type="wicri:doubleKey">0306-4522:2002:Lu J:somatostatin:modulates:the</idno><idno type="wicri:Area/Main/Merge">003497</idno><idno type="wicri:Area/Main/Curation">003053</idno><idno type="wicri:Area/Main/Exploration">003053</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Somatostatin modulates the behavioral effects of dopamine receptor activation in parkinsonian rats</title><author><name sortKey="Lu, J Q" sort="Lu, J Q" uniqKey="Lu J" first="J. Q." last="Lu">J. Q. Lu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Purdy Pavilion, 2221 Wesbrook Mall</s1><s2>Vancouver, BC, V6T 2B5</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC, V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Purdy Pavilion, 2221 Wesbrook Mall</s1><s2>Vancouver, BC, V6T 2B5</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC, V6T 2B5</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agonist</term><term>Animal</term><term>Dopamine receptor</term><term>Experimental disease</term><term>Parkinson disease</term><term>Rat</term><term>Somatostatin</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Somatostatine</term><term>Agoniste</term><term>Récepteur dopaminergique</term><term>Parkinson maladie</term><term>Pathologie expérimentale</term><term>Animal</term><term>Rat</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Somatostatin may play a role in several neuropsychiatric disorders, including Parkinson's disease. Although functional interactions between somatostatinergic and dopaminergic transmitter systems have been well documented, no study has been conducted in animals with experimental Parkinsonism to explore the effects of somatostatin on dopamine receptor-mediated behavior. In the present study, rats with unilateral 6-hydroxydopamine-induced destruction of the medial forebrain bundle were assessed following administration of the dopamine<sub>1/2</sub> receptor agonist apomorphine. Ipsilateral intrastriatal infusion of somatostatin produced a dose-related inhibition of apomorphine-induced rotations with maximal effect at a dose of 7.5 μg in 2 μl. This inhibitory effect of somatostatin was antagonized by the somatostatin antagonist cyclo-somatostatin (0.1 μg in 2 μl, intrastriatally). Neither somatostatin (up to 15 μg in 2 μl) nor cyclo-somatostatin on its own induced rotations; similarly, this dose of cyclo-somatostatin did not affect apomorphine-induced rotations. From these results we suggest that exogenous somatostatin, by directly acting on its specific receptors in the striatum, inhibits the effects of dopamine receptor activation in parkinsonian rats. We conclude that therapies based on modulation of somatostatin may be worth exploring in the management of Parkinson's disease and other disorders of the basal ganglia.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Lu, J Q" sort="Lu, J Q" uniqKey="Lu J" first="J. Q." last="Lu">J. Q. Lu</name></noRegion><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A. J." last="Stoessl">A. J. Stoessl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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